SLU-PP-332
ERR (Estrogen-Related Receptor) Pan-Agonist | Exercise Mimetic Research Compound
Product Name: SLU-PP-332
CAS Number: 2138663-23-7
Molecular Formula: C22H22N2O4
Molecular Weight: 378.42 g/mol
Purity: ≥99% (verified by HPLC & Mass Spectrometry)
Appearance: Off-white to pale crystalline powder
Quantity: 250mcg per dose — solution or powder format available
Product Overview
SLU-PP-332 is a novel synthetic pan-agonist of the Estrogen-Related Receptors (ERRα, ERRβ, and ERRγ), developed by researchers at Saint Louis University. Unlike traditional estrogen receptors, ERRs are orphan nuclear receptors that play a critical role in regulating cellular energy metabolism, mitochondrial biogenesis, and oxidative capacity. SLU-PP-332 has gained substantial attention in the research community as a leading “exercise mimetic” candidate — a compound that may replicate certain metabolic and physiological adaptations associated with endurance training.
Mechanism of Action
SLU-PP-332 directly activates all three ERR isoforms (α, β, γ), triggering downstream transcriptional programs that govern mitochondrial function and energy metabolism. In preclinical research models, SLU-PP-332 has been observed to:
- Upregulate genes involved in fatty acid oxidation
- Enhance mitochondrial biogenesis and oxidative phosphorylation
- Improve endurance and exercise capacity in animal models
- Promote conversion of fast-twitch (Type II) to slow-twitch (Type I) muscle fibers
- Reduce adipose tissue accumulation and improve metabolic flexibility
- Modulate glucose homeostasis and insulin sensitivity
Research Applications
- Exercise mimetic and endurance research
- Mitochondrial biogenesis and function studies
- Obesity and metabolic syndrome models
- Type 2 diabetes and insulin resistance research
- Sarcopenia and age-related muscle decline investigations
- Heart failure and cardiac metabolism studies
- Fatty acid oxidation pathway research
