IGF-1 LR3 1000mcg Kit

Long R3 Insulin-like Growth Factor-1 | 10 Vials × 100mcg

Product Name: IGF-1 LR3 (Long Arg3 Insulin-like Growth Factor-1)
CAS Number: 946870-92-4
Molecular Formula: C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉
Molecular Weight: 9117.6 g/mol
Purity: ≥99% (verified by HPLC & Mass Spectrometry)
Appearance: White lyophilized powder
Packaging: Sold as a kit of 10 vials × 100mcg (1000mcg / 1mg total)

Product Overview

IGF-1 LR3 is a synthetic, modified analog of Insulin-like Growth Factor-1, engineered with an arginine substitution at position 3 and a 13-amino-acid N-terminal extension. These modifications dramatically reduce its binding affinity to IGF binding proteins (IGFBPs), resulting in a significantly extended half-life of approximately 20–30 hours — compared to just 10–20 minutes for native IGF-1.

Each kit contains 10 individual 100mcg vials, providing exceptional dosing precision, extended shelf life, and reduced contamination risk between research sessions.

Mechanism of Action

IGF-1 LR3 binds to the IGF-1 receptor (IGF-1R), activating downstream signaling cascades including the PI3K/Akt and MAPK pathways. Its enhanced bioavailability and resistance to IGFBP sequestration make it approximately 2–3 times more potent than native IGF-1 in research models. Key effects observed in studies include:

• Stimulation of cellular proliferation and differentiation
• Promotion of protein synthesis and amino acid uptake
• Inhibition of apoptosis (programmed cell death)
• Enhanced glucose transport and metabolism
• Hyperplasia (increase in cell number) modeling

Research Applications

• Muscle cell proliferation and hypertrophy studies
• Investigations into IGF-1 receptor signaling pathways
• Cellular regeneration and recovery research
• Neuroprotection and neural growth studies
• Bone density and skeletal development models
• Cancer pathway research (proliferation markers)
• Diabetes and insulin sensitivity studies

Reconstitution & Storage

Reconstitution: Use bacteriostatic water or sterile saline. Typical dilution is 1 mL per 100mcg vial for precise microdosing in research protocols.
Storage (Lyophilized): Store at -20°C for long-term stability. Stable at room temperature for short transit periods.
Storage (Reconstituted): Refrigerate at 2–8°C and use within 14–21 days. Do not freeze reconstituted solution.
Shelf Life: 24 months from manufacture date when stored properly.

Kit Contents

• 10 × 100mcg lyophilized IGF-1 LR3 vials (sealed, sterile)
• Tamper-evident flip-off caps
• Batch-specific lot number on each vial
• Certificate of Analysis (COA) available upon request

Why a 10-Vial Kit?

• Maximum shelf life — Unopened lyophilized vials stay stable far longer than a single reconstituted bulk vial
• Dosing accuracy — 100mcg increments allow precise research protocols
• Reduced degradation risk — Smaller working volumes mean fresher peptide at every stage
• Lower contamination exposure — Fresh vials reduce repeated puncture risks

Quality Assurance

Every batch is independently third-party tested for purity, identity, and sterility. HPLC and Mass Spectrometry reports are available with your order. Manufactured in an ISO-certified facility under strict GMP-aligned standards to ensure batch-to-batch consistency.

Sequence

Met-Phe-Pro-Ala-Met-Pro-Leu-Ser-Ser-Leu-Phe-Val-Asn-Gly-Pro-Arg-Thr-Leu-Cys-Gly-Ala-Glu-Leu-Val-Asp-Ala-Leu-Gln-Phe-Val-Cys-Gly-Asp-Arg-Gly-Phe-Tyr-Phe-Asn-Lys-Pro-Thr-Gly-Tyr-Gly-Ser-Ser-Ser-Arg-Arg-Ala-Pro-Gln-Thr-Gly-Ile-Val-Asp-Glu-Cys-Cys-Phe-Arg-Ser-Cys-Asp-Leu-Arg-Arg-Leu-Glu-Met-Tyr-Cys-Ala-Pro-Leu-Lys-Pro-Ala-Lys-Ser-Ala