SR9011
Rev-ErbA Agonist | Circadian Rhythm Research Compound
Product Name: SR9011
CAS Number: 1416133-89-5
Molecular Formula: C23H33ClN4O2S
Molecular Weight: 465.05 g/mol
Purity: ≥99% (verified by HPLC & Mass Spectrometry)
Appearance: Off-white to pale yellow crystalline powder
Quantity: 600mg (20mg × 30 servings) — solution or powder format available
Product Overview
SR9011 is a synthetic agonist of the Rev-ErbA (Rev-Erbα and Rev-Erbβ) nuclear receptors, originally developed at the Scripps Research Institute. As a key regulator of the circadian clock and metabolic gene expression, Rev-ErbA plays a central role in modulating lipid metabolism, glucose homeostasis, and inflammatory pathways. SR9011 has attracted significant attention in research circles for its ability to influence metabolic and circadian processes at the molecular level.
Mechanism of Action
SR9011 binds to and activates Rev-ErbA nuclear receptors, which function as transcriptional repressors of genes involved in circadian rhythm regulation (including BMAL1) and metabolic processes. By modulating these pathways, SR9011 has been observed in research models to:
- Alter the expression of core circadian clock genes
- Increase mitochondrial biogenesis in skeletal muscle tissue
- Influence lipid and cholesterol metabolism pathways
- Reduce inflammatory cytokine expression
- Modulate glucose and fatty acid oxidation
Research Applications
- Circadian rhythm and biological clock studies
- Metabolic disorder research (obesity, dyslipidemia models)
- Mitochondrial function and biogenesis investigations
- Exercise performance and endurance research models
- Sleep-wake cycle modulation studies
- Inflammation and atherosclerosis pathway research
- Cancer cell metabolism studies (autophagy & apoptosis pathways)
Comparison: SR9011 vs. SR9009
SR9011 is structurally related to its better-known analog SR9009 (Stenabolic). Both compounds target Rev-ErbA receptors, but SR9011 demonstrates a longer half-life in preclinical models (~4–6 hours vs. ~2–4 hours for SR9009), making it a preferred candidate for research protocols requiring extended receptor activation. Like SR9009, SR9011 exhibits poor oral bioavailability, which remains a key area of pharmacokinetic investigation.
Storage & Handling
Storage: Store in a cool, dry place away from direct sunlight. Refrigeration (2–8°C) is recommended for long-term stability.
Solution Format: Keep tightly sealed and refrigerated after opening. Use within 60–90 days.
Powder Format: Stable for 24 months when stored properly in a sealed container with desiccant.
Handling: Wear appropriate PPE. Avoid inhalation, ingestion, or skin contact.
Quality Assurance
Every batch is independently third-party tested for purity, identity, and consistency. HPLC and Mass Spectrometry reports are available with your order. Manufactured in an ISO-certified facility under strict quality control standards to ensure batch-to-batch reliability.
Key Research Highlights
- Novel target — One of the few known Rev-ErbA agonists available for research
- Non-hormonal — Does not bind to androgen or estrogen receptors
- Metabolic focus — Heavily studied in mitochondrial and lipid metabolism contexts
- Circadian relevance — Unique tool for studying biological clock mechanisms
⚠️ Important Notice
FOR LABORATORY RESEARCH USE ONLY. This product is not intended for human or veterinary use, diagnostic procedures, food additives, cosmetics, household applications, or any form of in-vivo administration. Sold exclusively to qualified researchers and licensed institutions. Must be handled by trained professionals in appropriate laboratory settings. Not approved by the FDA or any regulatory agency for human consumption.
